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Abstract Title:Protective effect of melatonin on learning and memory impairment and hippocampal dysfunction in rats由高果糖玉米糖浆诱导。
摘要来源：
伊朗J基本医学Sci。 2023年1月； 26（1）：69-75。 PMID： 36594054“> 36594054 Oguzhan Kavrik, Hikmet Orhan
Article Affiliation:Arzu Yalcin
Abstract:OBJECTIVES: We investigated the harmful effects of high fructose corn syrup (HFCS) on learning and memory in the hippocampus and the ameliorative effects of melatonin 。D分为三组：I组，对照；第二组，HFCS；和第三组HFCS+MEL。 HFC形式F55作为20％果糖糖浆溶液制备。将HFC和HFCS+MEL组的大鼠饮用水10周。除HFCS 55外，HFCS+MEL组中的大鼠口服了10 mg/kg/day褪黑激素。莫里斯水迷宫（MWM）测试还适用于所有动物5天，以确定其学习和记忆水平。 After decapitation, one-half of the hippocampus samples were collected for western blot analysis, and another half of the tissues were collected for histopathological and immunohistochemical analyses.
RESULTS: In the HFCS group, there was a significant difference between the time to find the platform in the MWM test and time在第1到第5天之间花费在象限中（分别为p = 0.037和p = 0.001）。此外，MT1A受体，TNF-α，Inos，骨桥蛋白（OPN）和INT的水平降低HFCS组的Erleukin-6（IL-6）表达显着增加。褪黑激素治疗逆转了MT1A受体水平和TNF-α，Inos，OPN和IL-6表达。在组织病理学检查期间，HFCS组观察到神经元变性的增加。褪黑激素改善了这些变化。
结论： HFC的消耗导致成年大鼠学习和记忆力的恶化。我们建议褪黑激素有效地防止学习和记忆障碍。