用富含氢的电解水和茶多酚对氧化应激,肠道损伤和热压力小鼠的肠道菌群破坏的影响。
J Therm Biol. 2024 Jul ;123:103921. Epub 2024 Jul 18. PMID: 39032288
Yao Zang
热应激(HS)会对生物体造成损害,尤其是肠道。在本文中,我们研究了小鼠中茶多酚(TP)和富含氢的电解水(HRW)的联合作用的影响。通过体外抗氧化活性测定法筛选了腹膜内注射的HRW进食和TP的组合。结果表明,与TP和HRW的各自处理相比,合并治疗对减轻HS对小鼠行为,生长性能,氧化损伤和肠道的影响更有帮助(P <0.05)。 Additionally, the combined treatment could repair HS-induced intestinal dysbiosis in mice, augmenting the number and abundance of bacteria, increasing the number of beneficial genera (Lachnospiraceae_NK4A136_group and Lactobacillus), and decreasing the number of harmful genera (Desulfovibrio and Enterorhabdus), and the effect was significantly better than that of individual treatment (p <0.05)。总之,TP和HRW的联合治疗有效地减轻了HS对小鼠行为,生长性能,氧化损伤和肠道营养不良的不利影响,超过了单独使用TP或HRW治疗的疗效。