脂质健康疾病。 2018年5月24日; 17(1):123。 EPUB 2018 5月24日。PMID: 29793496 29793496 Ostadmohammadi, Kamran B Lankarani, Payam Peymani, Maryam Akbari, Fariba Kolahdooz, Zatollah Asemi
Article Affiliation:Reza Tabrizi
Abstract:BACKGROUND: Several studies have evaluated the effect of补充代谢疾病人群中脂质谱的肌醇;但是,这些发现是有争议的。此随机评论controlled trials (RCTs) was performed to summarize the evidence of the effects of inositol supplementation on lipid profiles among population with metabolic diseases.
METHODS: Relevant RCTs studies were searched in Cochrane Library, EMBASE, MEDLINE, and Web of Science until October 2017. Two researchers assessed研究资格,提取数据并评估纳入的基本研究的偏见风险。为了检查纳入的研究Q检验和ISTATISTIS的异质性。通过使用随机效应模型合并数据,并将标准化的平均差异(SMD)视为效应大小的摘要。
结果: 总体上,总体上包含14个RCT。汇总结果表明,代谢性疾病患者的肌醇补充显着降低了甘油三酸酯(SMD -1.24; 95%CI,-1.84,-0.64; P <0.001),总 - (SMD -1.09; 95%CI,-1.83,-0.55; P <0.001)和LDL-胆固醇水平(SMD -1.31; 95%CI,-2.23,-0.39; P = 0.005)。 There was no effect of inositol supplementation on HDL-cholesterol levels (SMD 0.20; 95% CI, - 0.27, 0.67; P = 0.40).
CONCLUSIONS: Inositol supplementation may result in reduction in triglycerides, total- and LDL-cholesterol水平,但不影响代谢性疾病患者的HDL-胆固醇水平。有关补充肌醇对代谢疾病患者脂质谱的影响的其他前瞻性研究是必要的。