葡萄和苹果汁对大鼠肾脏中镉中毒的保护作用。
摘要来源:
药物res(Stuttg)。 2020年8月20日。epub 2020年8月20日。pmid: 32820471“> 32820471”> 32820471 De Moura,Caroline Margonato Cardoso,Aline Boveto Santamarina,Luciana Pellegrini Pisani,Daniel Araki Ribeiro
文章隶属关系:bianca andrade andrade handan
effect of grape and apple juices against toxicity induced by cadmium in the kidney of rats.METHODS: A total of 20 male-Wistar rats were distributed into four groups (n=5): Control group: animals received an intraperitoneal (i.p.) injection of 0.9% saline solution and after15天,通过烤架施用1毫升的水15天;镉组:动物接受了腹膜内注射的氯化镉(1.2 mg/kg),15天后,通过饲料进行了15天的水15天。镉+葡萄汁:动物接受了I.P.注射氯化镉(1.2 mg/kg),15天后,通过饲料施用0.8 mL葡萄汁15天;镉+苹果汁:收到的动物I.P. injection of cadmium chloride (1.2 mg/kg) and after 15 days, 1.0 mL of apple juice was administered for 15 days, via gavage.
RESULTS: Histopathological analysis revealed severe tubular lesion and necrosis in the group exposed to cadmium, while animals exposed to grape或苹果果汁显示组织损伤的显着减少。在处理的动物中,8-OHDG免疫表达,DNA损伤,细胞色素c和过氧化氢酶基因表达以及信号通路(TLR2和PIKKα/β)的TOLL降低了。与镉组相比。中毒。