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Abstract Title:Ameliorating Effect of(Celery) Extracts on IL-6 Plasma Level and Expression of Caspase 3 on Liver in Animal Model of Lead Intoxication.
Abstract Source:
pak j biol Sci。 2024年1月； 27（2）：52-58。 PMID： 38516746 38516746 Trisnadi, Hadi Sarosa, Titiek Kusumarawati, Chodijah, Agung Putra
Article Affiliation:Rizqa Razaqtania
Abstract:Background and Objective: Lead poisoning (Pb) is a big problem because it is found in almost all objects in daily life such as vehicle fuel, water pipes, ceramics, cosmetics and others.连续铅暴露会增加ROS，从而导致肝IL-6和胱天蛋白酶3的增加，从而取代肝细胞凋亡。这是S的研究是为了确定Apium graveolens （芹菜）提取物对等离子体IL-6和肝caspase 3级的影响。材料和方法：这项研究使用了测试后对照组设计。研究受试者是符合纳入标准的20个Wistar大鼠，并将其分为4组，即（a）没有治疗的假手术组，（b）用乙酸铅200mg kg 1 1 1 1 1 1 1 身体体重/天，没有任何治疗方法（c）阳性对照组和（d）治疗组。在第15天，通过免疫组织化学方法将血液检查以检查IL-6水平，并采用组织进行肝胱天冬酶3检查。 Data analysis used the one-way ANOVA test and continued with thepost hoc LSD test.Results: The highest mean caspase 3 expression was in the control group 45.84±4.39 pg mL1, while the mean of IL-6 plasma level was highest in the P1 641.33±39.72 pg ML 1 组。 Mann-Whitney测试表现出色研究组之间IL-6水平的差异（p = 0.000）。 Mann-Whitney测试在研究组之间显示caspase 3水平有显着差异（p = 0.000）。