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Abstract Title:Low magnesium in conjunction with high homocysteine increases DNA damage in healthy middle aged澳大利亚人。
摘要来源：
eur J Nutr。 2024年6月12日。epub 2024 6月12日。PMID： 3886486565 Deo，Michael Fenech
文章隶属关系：varinderpal s dhillon
摘要：
目的： 镁镁是人体中最常见的元素，并且扮演着enzemes的重要机制之一，并涵盖了许多dna的机制，并且涵盖了dna dna dna and dna and dna and and dna and dna and and dna and and dna and and and dna dna传感和调节一种碳代谢缺陷。在Parti中，低摄入镁可以增加许多疾病的风险Cular，慢性退化性疾病。但是，到目前为止，尚未对其在预防DNA损伤中的作用进行全面研究。 Therefore, we tested the hypothesis that magnesium deficiency either on its own or in conjunction with high homocysteine (Hcy) induces DNA damage in vivo in humans.
METHODS: The present study was carried out in 172 healthy middle aged subjects from South Australia.测量了镁，HCY，叶酸和维生素的血液水平。进行细胞因子阻塞微核细胞体分析以测量三种DNA损伤生物标志物：微核（MN），核质桥（NPB）和核芽（NBUD）和周围血液淋巴细胞中的核芽（NBUD）。镁和HCY彼此之间显着呈除多,， r = -0.299，p <0.0001）。此外，镁与叶酸（P = 0.002）和维生素B呈正相关（p = 0.007）。镁也与MN（P <0.0001）和NPB（P <0.0001）显着相关。与高镁和低HCY的患者相比，低镁和高HCY的个体显示出MN和NPB的频率明显更高（P <0.0001）。 Furthermore, there was an interactive effect between these two factors as well in inducing MN (p = 0.01) and NPB (p = 0.048).
CONCLUSIONS: The results obtained in the present study indicate for the first time that low in vivo levels of magnesium either on its own or in the presence of high Hcy增加了MN和NPB的频率更高的DNA损伤。