naringin保护小鼠免受D-半乳糖诱导的肺老化和线粒体功能障碍：SIRT1途径的含义。
摘要来源：
life sci。 2023年7月1日; 324：121471。 EPUB 2023 2月4日。PMID： 36746356“> 36746356 Mansour
文章隶属关系：abeer a salama
摘要：
aim： 衰老是减少肺功能的主要风险因素，以及损伤和肺部疾病。 The target of our research was to examine the potential protective effect of naringin and the possible role of SIRT1 in mice with D-galactose-induced lung aging, by evaluating its effects on antioxidant systems, mitochondrial biogenesis, autophagy, and apoptosis, by referring to the potential involvement of Nrf2/NQO1, LKB1/AMPK/PGC-1α, FOXO1, and p53/caspase-3信号传导。 p>
MATERIAL AND METHODS: The mice were randomly sorted into 5 groups (10 each): 1stnormal group received subcutaneous normal saline and intragastric distilled water, 2ndnaringin 300 mg/kg orally, 3rdD-galactose (200 mg/kg/day) was administered subcutaneously进入小鼠八周，以加速衰老，第四和第五：口服Naringin（150，300mg/kg），每天同时将8周的D-半乳糖注入。
SIGNIFICANCE: Naringin exerts protective effects against D-galactose-induced lung aging and enhances longevity by activating SIRT1. SIRT1通过恢复促氧化剂/抗氧化剂稳态，激活线粒体生物发生，自噬和抑制细胞凋亡。