berberine对小鼠中吗啡诱导的条件位置偏好的获取和恢复的影响。
摘要来源:
avicenna j phytomed。 2016 Mar-Apr; 6(2):198-204。 PMID: 27222833“> 27222833 埃德里斯·阿克巴里(Edris Akbari),莫赫森·艾森希迪(Mohsen Imenshidi),霍斯辛·霍斯辛扎德(Hossein hosseinzadeh)
文章隶属关系:faezeh vaezeh vahdati hassani
摘要:
MATERIALS AND METHODS: In male NMRI mice, the acquisition of CPP was established by 40 mg/kg of morphine sulphate injection and extinguished after the灭绝训练,并通过注射10 mg/kg的吗啡来恢复。 The effects of different doses of berberine (5, 10, and 20 mg/kg) on the acquisition and reinstatement induced by morphine were evaluated in a conditioned place preference test.
RESULTS: The results showed that intraperitoneal administration of berberine (5, 10, and 20 mg/kg) did not induce有条件的食欲或厌恶作用。在吗啡给药前2小时注射小ber碱(10 mg/kg)减少了吗啡诱导的CPP的获取。另外,相同剂量的小ber可以显着阻止重新定位吗啡诱导的CPP。
结论: