元素饮食通过粘液屏障的改变调节了5-氟尿嘧啶诱导的胃肠道粘膜炎。
摘要来源：
癌症化学药品。 2015年8月； 76（2）：269-77。 EPUB 2015年6月6日。PMID： 26048344 26048344 Tatsunori Maekawa，Hajime Yamamoto，Wasaburo Koizumi，Takafumi Ichikawa
文章隶属关系：rei kawashima
摘要：
抗肿瘤化疗。尽管这种有效性可能部分是由于养分吸收高，但化学疗法对粘膜防御机制的影响尚不清楚。我们研究了5-氟尿嘧啶（5-FU）诱导的肠粘膜炎的口服补充对粘蛋白的影响。
METHODS: 5-FU was administered to rats orally once daily, and ED was supplied orally twice daily for 5 days. The severity of mucositis was assessed by length, dry tissue weight, and villus height of the intestinal tract. Using anti-mucin monoclonal antibody, we compared the immunoreactivity in the gastrointestinal (GI) tract and mucin content by histological and biochemical examinations.
RESULTS: Oral supplementation with ED reduced histological damage and loss of length, dry tissue weight, and villus height induced by 5-FU administration. ED markedly altered PGM34 antibody immunoreactivity and mucin contents in the small intestine of rats with 5-FU-induced mucositis.
CONCLUSIONS: ED may possibly be more effective for the prevention of antineoplastic chemotherapy-induced mucositis through the activation of GI mucus cells.