姜黄素在Zymosan诱导的多器官功能障碍综合征中的保护作用

Sushun Liu

AIM: Multiple Organ Dysfunction Syndrome (MODS) is characterized as progressive and uncontrolled inflammatory response which涉及炎症级联反应，细胞因子释放和内皮功能障碍的激活，导致几种器官功能恶化。姜黄素是与姜黄的黄色有关的天然多酚，据报道可以发挥抗炎，抗癌，抗氧化和抗肿瘤作用。我们进行了研究to investigate the effects of curcumin in non-septic MODS caused by zymosan in mice model.

METHOD: The mice were randomly allocated into 5 groups (6 mice per group): Control group (treated with physiological saline, 0.1 ml daily for 3 days before and 1 hour after physiological saline treatment), DMSO group (treated with DMSO, 0.1 ml daily for 3 days before and 1 hour after physiological saline treatment), Curcumin group (200 mg/kg, suspended in DMSO, in a final volume of 0.1 ml, used for 3 days daily before and 1 hour after physiological saline treatment), Zymosan+ DMSO group (treated with DMSO, 0.1 ml daily for 3 days before and 1 hour after zymosan treatment) and Zymosan+姜黄素基（用姜黄素处理，每天以0.1 ml剂量悬浮在DMSO中，持续3天，酶治疗后1小时）。牺牲组中的小鼠，然后收集血液和组织以评估急性腹膜的严重程度在注射Zymosan或生理盐水后18小时，TIS，组织组织病理学变化，无形成，氧化应激，PMN浸润，细胞因子产生，器官功能和NF-κB激活。 In another set of experiment, the mice were also grouped (20 mice per group) for monitoring the loss of body weight and mortality for 7 days after zymosan or physiological saline administration.

RESULTS: Curcumin induces a significant reduction of the volume exudate and the neutrophil infiltration.它还可以通过减少NO形成，氧化应激，细胞因子产生和炎性细胞的浸润，从而对组织病理学损伤具有出色的保护作用。姜黄素的给药也可以改善器官功能。此外，在mods小鼠模型中，姜黄素会减弱NF-κB的激活，这表明姜黄素通过抑制ex抑制Zymosan诱导的MOD衰减可能的NF-κB压力。此外，姜黄素处理的小鼠被证明可减轻MOD的严重程度，其特征是次系统毒性，减少体重减轻和由Zymosan给药引起的较低的死亡率。

sub_abstract_label“>结论： mods。