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Abstract Title:Dynamic Balance of Microglia and Astrocytes Involved in the Remyelinating Effect of Ginkgolide b。
摘要来源：
前细胞神经科学。 2019; 13：572。 EPUB 2020 JAN8。PMID： 31969806 Miao, Ruo-Xuan Sui, Qing Wang, Jie-Zhong Yu, Bao-Guo Xiao, Cun-Gen Ma
Article Affiliation:Jun-Jun Yin
Abstract:Multiple sclerosis (MS) is an inflammatory demyelinating disorder in the central nervous system (CNS), in which remyelination failure results in persistent neurologic impairment. Ginkgolide B（GB）是Ginkgo Biloba的主要萜烯内酯和活性成分，在几种神经系统疾病模型中具有神经保护作用。我们的结果表明，这里by using ancuprizone (CPZ)-induced demyelinating model, administration of GB improved behavior abnormalities, promoted myelin generation, and significantly regulated the dynamic balance of microglia and astrocytes by inhibiting the expression of TLR4, NF-κB and iNOS as well as IL-1βand TNF-α, and up-regulating the expression of Arg-1 and neurotrophic factors. GB处理还诱导了少突胶质细胞前体细胞（OPC）的产生。细胞实验得出的结果与theSodel相似。通过减少小胶质细胞介导的神经炎症并促进星形胶质细胞衍生的神经营养因子来有助于内源性透明度，通过减少小胶质细胞介导的神经炎症和促进动态平衡。尽管GB治疗可能代表了促进髓磷脂恢复的新策略，但GB靶向小胶质细胞和星形胶质细胞的确切机制仍有待进一步探讨。