Click here to read the complete article.
Abstract Title:Anti-inflammatory and immunoregulatory effects of icariin and iCaritin。
摘要来源：
生物形成药物。 2022年7月; 151：113180。 Epub 2022 May 27. PMID: 35676785
Abstract Author(s):Zhangyang Bi, Wei Zhang, Xiaoyan Yan
Article Affiliation:Zhangyang Bi
Abstract:Inflammation and immunity dysregulation have received widespread attention in recent years due to their occurrence in the pathophysiology of many conditions. In this regard, several pharmacological studies have been conducted aiming to evaluate the potential anti-inflammatory and immunomodulatory effects of phytochemicals. epimedium是一种传统的中药，通常用作滋补品，壮阳药和抗疾病绅士。 ICARIIN（ICA）是epimedium的主要活性成分，一旦摄入，主要被代谢成伊卡汀（ICT）。 Data from in vitro and in vivo studies suggested that ICA and its metabolite (ICT) regulated the functions and activation of immune cells, modulated the release of inflammatory factors, and restored aberrant signaling pathways. ICA and ICT were also involved in anti-inflammatory and immune responses in several diseases, including multiple sclerosis, asthma, atherosclerosis, lupus nephritis, inflammatory bowel diseases, rheumatoid arthritis, and cancer.然而，数据表明，ICA和ICT表现出相似但不相同的药代动力学特性。 Therefore, based on their higher solubility and bioavailability, as well as trends indicating that single-ingredient compounds offer broader and safer therapeutic capabilities, ICA and ICT delivery systems and treatment represent interesting avenues with promising clinical applications.在这项研究中，我们回顾了抗炎和免疫调节机制，以及ICA及其代谢物ICT的药代动力学特性。