麻疹和腮腺炎与心血管疾病的关联:日本协作队列(JACC)研究。
摘要来源:
动脉粥样硬化。 2015年8月; 241(2):682-6。 EPUB 2015年6月18日。PMID: 26122188 26122188 Akiko Tamakoshi,
Article Affiliation:Yasuhiko Kubota
Abstract:OBJECTIVE: Although it has been suggested that exposure to infections during childhood could decrease risk of atherosclerotic cardiovascular disease (CVD), the evidence is scarce. We investigated the association of measles and mumps with CVD.
METHODS: 43,689 men and 60,147 women aged 40-79 years at baseline (1988-1990) completed a lifestyle questionnaire, including their history of measles and mumps, and were followed until 2009.感染史分类为没有感染(参考),仅麻疹,仅腮腺炎或两种感染。计算了CVD死亡率的危险比(HR)。 (0.28-0.94)的总中风,出血性中风0.21(0.05-0.86),而两种感染的患者的总CVD为0.80(0.71-0.90),CVD,0.71(0.53-0.93)的心肌梗死和0.83(0.83)(0.83(0.83)(0.83(0.69-0.98))的总restect。两种感染的妇女的总CVD为0.83(0.74-0.92),总中风为0.84(0.71-0.99)。我们还只用麻疹或仅腮腺炎(参考)和两种感染的受试者进行了比较。两种感染的男性的总CVD为0.88(0.78-0.99)。两种感染的妇女的总CVD为0.85(0.76-0.94),总中风为0.79(0.67-0.93)E,缺血性中风0.78(0.62-0.98),出血性中风0.78(0.62-0.98)。 CVD。