营养抑制肌肉蛋白水解:硫化硫化物在治疗肌肉浪费中的作用。
摘要来源:
Clin Nutr。 2011年2月; 30(1):33-7。 EPUB 2010年7月22日。PMID: 20655130 20655130 Cibely Fontes de Oliveira,MíriamToledo,Angelica Sette,Paula Ventura da Silva,Pablo Barberis,Josep MArgilés,FranciscoJLópez-Soriano
文章隶属 645, Barcelona 08028, Spain.Abstract:BACKGROUND & AIMS: The abnormalities associated with cancer cachexia include anorexia, weight loss, muscle loss and atrophy, anaemia and alterations in carbohydrate, lipid and protein metabolism.现在的目的investigation was to examine the anti-wasting effects of some nutraceuticals such as genistein, resveratrol, epigallocatechin gallate and diallyl sulphide (DAS).
METHODS: The in vitro effects of these nutraceuticals on proteolysis were examined in muscle cell cultures提交给热疗。还测试了DAS的体内效应在含有缓存的肿瘤大鼠(Yoshida AH-130腹部肝瘤)中。
结果: span> spans,尽管所有的营养均抑制了肌肉蛋白质的蛋白质分解,但均与PROME效应相关。体内给药DAS仅导致胫骨肌肉和心脏体重的改善。但是,对健康动物的给药增加了所有肌肉的体重,这与蛋白水解系统成分的基因表达降低有关。
结论: 可以建议在健康条件下使用DAS来改善肌肉质量。