摘要来源： ppar res。 2017; 2017：2647129。 EPUB 2017年5月30日。PMID： 28638404 Wu，Zhang，di fan，Yan Che，Zhao-peng Wang，Yang Xiao，Sha-sha Wang，Qi-Zhu Tang ya-ge jin intrans in froul from froul sange：草药kudzu根。瓜素在中国诊所被广泛用作辅助治疗。但是对其对调节心脏纤维化的影响知之甚少。 METHODS: Mice were subjected to transverse aorta constriction (TAC) for 8 weeks; meanwhile puerarin was given 1 week after TAC. Cardiac fibrosis was assessed by pathological staining. The mRNA and protein changes of CD31 and vimentin in both animal and human umbilical vein endothelial cells (HUVECs) models were detected. Immunofluorescence进行CD31和波形蛋白的共定位和刮擦测试以检查TGF-β1诱导的HUVEC变化。 苏蛋白酶诱发的心脏纤维化，伴随着抑制的内皮到间质跃迁（EndMT）在HUVEC中产生保护作用，而GW9662逆转了Puerarin造成的。 结论： puerarin侵害了TAC诱导的心脏纤维化效果，并且在PAR上施加了这种保护效果，并且在PAR上可能会灭绝。 TGF-β1/SMAD2介导的Endmt。