辅酶Q10通过严重减少梗塞区域，炎症和氧化应激，预防心肌梗塞的急性后遗症

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Coenzyme Q10 protects against acute consequences of experimental myocardial infarction in大鼠。

int J Physiol Physiol Physophyolypharsiol Pharmacol。 2015; 7（1）：1-13。 EPUB 2015 3月20日。PMID： 26069524“> 26069524 Sanjoy Ghosh，Fahaid al-Hashem，Abdullah S Shatoor，Abdulmohsen Alhejaily，Mohammad a Khalil a Khalil

samy m eleawa

METHODS: Male Wistar rats were randomly divided into six groups: control without surgery, sham without occlusion, MI without antioxidants, RES pre-treated then MI (20 mg/kg, orally), CoQ10 then MI (20 mg/kg, intramuscular.), and combined RES and CoQ10 then MI with (each group n = 10）。预处理在左前降降（LAD）冠状动脉永久闭塞前7天开始。在MI后24小时评估梗塞区域，血液动力学，炎症和氧化应激标志物。

结果： 与Res Holy，COQ10 Pre-Admientation By本身或结合使用RES，显着降低了LV梗塞面积（57％），以及归一化的LV血液动力学参数，例如LVEDP（100％），LVSP（95.4％），LV +DP/DT和-DP/DT（分别为102和73.1％）。 COQ10还降低了血清脑脂肪肽的血清水平（70％），并降低了TNF-α（83.2％）和IL-6（83.2％）等各种循环炎症标记。 Regarding oxidative stress, TBARS scores were lowered with a concurrent increase in both superoxide dismutase and glutathione peroxidase activities with CoQ10 alone or in combination with RES.

CONCLUSION: Coenzyme Q10 protects against the acute sequelae of myocardial infarction.它严重降低了梗塞区域，炎症和氧化应激，同时使LV血液动力学归一化。