芦荟蛋白改善了心肌梗塞引起的心脏重塑

通过上调的SMAD7抑制TGF-β/Smad信号传导小鼠的MI-Emodin在小鼠中改善了心脏重塑。

phytomedicine。 2023 Jun; 114：154793。 EPUB 2023 3月30日。PMID： 37011420“> 37011420 Wen Li，Yunqi Liu，Jiapan Wang，Jia Wang，Yilian Yang，Yan Hao，Zhen Liang，Zhen Liang，Yiping Tao，Ye Yuan，Ye Yuan，Zhimin du

（AE）是一种自然中国药用植物的天然蒽醌提取物，已获得证明可预防急性心肌缺血。然而，它对慢性心肌梗塞（MI）后对心脏重塑的影响且可能的机制尚不清楚。

ascor： 这项研究研究了效果o o o o o of AE on cardiac remodeling and oxidative damage induced by myocardial infarction (MI) in vitro and explored the underlying mechanisms.

METHODS: Echocardiography and Masson staining were used to demonstrate myocardial dysfunction and fibrosis.通过TUNEL染色检测到细胞凋亡。 The expressions of fibrosis-related factors such as type I collagen,α-smooth muscle actin (α-SMA) and connective tissue growth factor (CTGF) were detected by Western blot.

RESULTS: Our data demonstrated that AE treatment significantly improved cardiac function, reduced structural remodeling, and患有心肌梗塞的小鼠的心脏凋亡和氧化应激减少。在体外，AE可以保护新生小鼠心肌细胞（NMCM）免受血管紧张素II（ANG II）诱导的心肌细胞肥大和凋亡，并显着抑制（P <0.05）Ang II诱导的活性氧物种（ROS）增加。 Furthermore, AE treatment significantly reversed the Ang ii-induced upregulation.

CONCLUSION: In summary, our work reveals for the first time that AE activates the TGF-βsignaling pathway by up-regulating Smad7 expression, which in turn regulates the expression of fibrosis-related genes,最终改善心脏功能，抑制慢性MI大鼠心脏纤维化和肥大的发展。