galangin通过增强自噬通量和抑制炎症来缓解心肌缺血 - 再灌注损伤。
摘要来源:
eur J Pharmacol。 2023年4月15日; 945:175621。 EPUB 2023 2月26日。PMID: 36849103“> 36849103 Xiang Wei,Yanan Qu,Rifeng Gao,Yang LV,Jingpu Wang,Yiwen Wang,Jie Yang,Jiatian Cao,Jiatian Cao,Feng Zhang,Junbo ge
文章隶属关系:Jian Zhang
jian zhang 摘要:摘要:p>
METHODS: After 45-min occlusion of the left anterior descending coronary artery, myocardial I/R was induced by滑结释放。手术前的一天和手术后,将小鼠腹膜内注射相同的盐水或GAL。使用超声心动图,2,3,5-三苯基四唑染色(TTC染色),蛋白质印迹和透射电子显微镜评估GAL的效果。 Primary cardiomyocytes and bone marrow-derived macrophages were extracted in vitro to measure the cardioprotective effects of Gal.
RESULTS: Compared with the saline-treated group, Gal significantly improved cardiac function and limited infarct enlargement after myocardial I/R.在Vivo和体外研究表明,在心肌I/R期间,GAL治疗促进了自噬。 GAL的抗炎作用在骨髓来源的巨噬细胞中得到了验证。这些结果强烈表明,GAL治疗可以减弱心肌I/R损伤。
结论: 我们的数据表明,GAL可以改善左心室射血分数,并通过促进自动化和