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Abstract Title:Astaxanthin Alleviates Inflammatory Response in Neonatal Necrotizing Enterocolitis Rats by调节NOD2/TLR4途径。
摘要来源：
gastroenterol res实践。 2023; 2023：6078308。 EPUB 2023 3月27日。PMID： 37021078“> 37021078 Zhou Jiang
文章隶属关系：Xuandong Zhang
摘要：
背景： necrotizing inecrotizing inecrotizing inecrotization inecrotization（NEC）通常与炎症反应的示例激活相关。在研究中已证明astaxanthin对抗炎反应具有积极和有利的影响。因此，研究astaxanthin在NEC疾病和its molecular mechanism.
OBJECTIVE: The present study was to investigate whether astaxanthin attenuates NEC rats and to explore its potential mechanism.Hematoxylin-eosin staining was used to observe the pathological change of the intestinal tissue in NEC rats.随后，我们用酶联的免疫吸附测定套件，TUNEL染色，蛋白质印迹和免疫组织化学分析确定了astaxanthin中抗氧化应激，抗凋亡和抗炎。 Furthermore, we added nucleotide-binding oligomerization domain 2 (NOD2) inhibitor to certify the molecular pathway of the astaxanthin in NEC rats.
RESULTS: Astaxanthin improved the pathological changes of the intestinal tissues.它限制了NEC大鼠的肠道组织和血清中炎症，氧化应激和受保护的细胞。此外，astaxanthin增强了nod2，其中因为它抑制了类似Toll样受体4（TLR4），核因子-B（NF-B）途径相关蛋白。 Apart from that, the NOD2 inhibitor offset the protective effect of the astaxanthin towards the NEC rats.
CONCLUSION: The present study indicated that astaxanthin alleviated oxidative stress, inflammatory response, and apoptosis in NEC rats by enhancing NOD2 and inhibiting TLR4途径。