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Abstract Title:Electroacupuncture alleviates orofacial allodynia and anxiety-like behaviors by regulating三叉神经痛小鼠模型中CA1海马区域的突触可塑性。
摘要来源:
前摩尔神经科。 2022; 15:979483。 EPUB 2022 10月6日。PMID: 36277498 36277498 Guang-Ming Zhang,Hong-Yun Wu,Si-Shuo Zhang,Hong-Wei Zhi,Ya-Han Wang,Jing-Wen Zhu,Yi-Fan Wang,Xiang-Qing Xu,Cai-Jun Tian,Wen-Jun Tian,Wen-Qiang cui yu p> yuu-Zhi jiA 目标: 三叉神经痛(TN)是最严重和令人衰弱的慢性疼痛状况之一,通常伴随着情绪障碍,例如焦虑症抑郁症。电针(EA)是对中药具有镇痛和抗焦虑作用的特征疗法。这项研究旨在调查EA是否通过改变海马CA1中突触可塑性来缓解异常TN tn tn tn tn tn的疼痛和焦虑症的行为EA用于治疗同侧针灸点(GV20-BAIHUI和ST7-XIAGUAN)。 Golgi-Cox staining and transmission electron microscopy (TEM) were administrated to observe the changes of synaptic plasticity in the hippocampus CA1.
RESULTS: Stable and persistent orofacial allodynia and anxiety-like behaviors induced by pT-ION were related to changes in hippocampal突触可塑性。高尔基染色显示树突状密度降低PT-ION小鼠的海马Ca1神经元中的刺,尤其是蘑菇型树突状刺。 TEM结果表明,突触的密度,突触后密度的膜厚度和突触活动区的长度降低,而PT-ION小鼠中突触裂口的宽度增加。衰减了PT-ION引起的口面异常性异常和焦虑行为,并有效地扭转了树突状棘的异常变化和海马CA1区域的突触。