Pain-relieving effects of Lawsonia inermis on neuropathic pain induced by chronic constriction injury.
Abstract Source:Metab Brain Dis. 2021年6月25日。epub 2021 6月25日。pmid： 34169409
摘要作者：hassan rakhshandeh， Amirhosein Ghorbanzadeh, Sajad Sahab Negah, Maryam Akaberi, Roghayeh Rashidi, Fatemeh Forouzanfar
Article Affiliation:Hassan Rakhshandeh
Abstract:The aim of this study was to determine the role of Lawsonia inermis (慢性狭窄损伤（CCI）诱导的L. inermis）提取物神经性疼痛。 CCI手术后，连续14天对腹膜内腹膜内进行了14天的腹膜内提取物（250 mg/kg和500 mg/kg）和加巴喷丁（100 mg/kg）。通过辐射热，乙酸下降和冯·弗雷丝测试评估热痛觉过敏和异常性疾病。在-1SH，3，第5，7上评估了大鼠疼痛行为th, 10th and 14th days post CCI surgery. At the end of the study, the spinal levels of malondialdehyde (MDA), total thiol, IL1-β, and TNF-α were estimated. Treatment of L. inermis extract reversed the decreased level of thiol and the elevation of MDA level in the spinal cord of CCI rats.此外，CCI大鼠脊髓中的炎症标志物（包括IL1-β和TNF-α）的升高升高。这些结果表明，无乳杆菌对CCI的抗氧化剂和抗炎作用具有潜在的神经保护作用。
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