用糖胺聚糖和抗氧化剂对口服补充的积极作用对膝关节中骨软骨缺损再生的抗氧化剂。
摘要来源:
Physiol res。 2007; 56(2):243-9。 EPUB 2006 3月23日。PMID: 16555950 16555950
摘要作者:
m Handl,E Amler,KBräun,J Holzheu,t trc,A B Imhoff,A lytvynets,efilová,efilová,hKolárová,kotyk,a kotyk,a kotyk,a kotyk,a kotyk,a kotyk, vartínek
摘要:
在兔子中研究了口服补充糖胺聚糖(GAG)(GAG)和自由基清除剂(维生素E/硒)对骨软骨缺陷再生的影响。在引入膝关节中定义的骨软骨缺损后,为十只动物组成了GAG/维生素E/硒混合物或安慰剂(牛奶糖)6周。牺牲后,进行了组织学和组织化学分析。滑液的量增加了placebo group, while the viscosity of the synovial fluid was significantly enhanced in the GAG group.在ogag组中,骨软骨再生的硫酸化插入量(8.8 +/- 3.6%vs. 6.0 +/- 5.6%; p <0.03)明显更高。 In both groups, the GAG amount in the cartilage of the operated knee was significantly higher than in the non-involved knee (p <0.05). Histological analysis of the regenerates in the GAG group was superior in comparison with the placebo group. For the first time, a biological effect following oral supplementation with GAG was demonstrated in healing of osteochondral defects in vivo. These findings support the known positive clinical results.
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