cinnamaldehede和Eugenol预防RAW 264.7细胞中LPS刺激的氧化应激和炎症。
摘要来源：
j食品生物化学。 2021 Oct 22:e13980. Epub 2021 Oct 22. PMID: 34676584
摘要作者：emine gulceri gulec peker，kaan kaltalioglu
文章隶属关系：emine guleci gulec peker
摘要：巨噬细胞是巨人的白细胞role in immune response and can be associated with various diseases due to their effects on the inflammation process and oxidative events.对当前的研究评估了肉桂醛和丁香酚的抗炎和抗氧化特性，它们是脂多糖（LPS）诱导的巨噬细胞上具有多种生物活性特性的植物化合物。 For this purpose, Raw 264.7 cells were incubated with cinnamaldehyde or eugenol (15, 25, and 50 μM) then stimulated withLPS。 After 24 hr, tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), and IL-6 levels (as inflammatory mediators), and malondialdehyde (MDA) and nitric oxide (NOx) levels as well as superoxide dismutase (SOD) and catalase (CAT) activities (as oxidative statusmarkers) were determined in cell cultures. Cinnamaldehyde and eugenol pre-treatments decreased TNF-α, IL-1β, and IL-6 levels as compared to LPS group at all concentrations. Furthermore, these pre-treatments increased SOD activity while decreased MDA and NOx levels as well as CAT activity at different concentrations. Our results demonstrated that these phyto-compounds have potential for the treatment of various diseases as protective agents against chronic inflammation and oxidative stress. PRACTICAL APPLICATIONS: Chronic inflammation and oxidative stress are complications that play a detrimental role in the pathophysiology of many diseases. Alternative treatment methods have been investigated to prevent them. Cinnamaldehyde和丁子香酚是具有高生物活性的植物化合物，可以从食品和香料中获得。在本研究中，研究了肉桂醛和丁子香酚对脂多糖诱导的巨噬细胞氧化应激和炎症的保护作用。根据获得的结果，肉桂醛和丁子香酚预处理可减少炎症并减少氧化应激。肉桂醛和丁子香酚可能是治疗慢性炎症和氧化应激相关疾病更好的天然替代保护剂。