罗布麻宁可降低谷氨酸钠在大脑中的细胞毒性作用：光谱、氧化负荷和机器学习研究。
摘要来源：Spectrochim Acta A Mol Biomol Spectrosc。 2022 年 10 月 15 日；279:121495。 Epub 2022 年 6 月 9 日。PMID：35700610
摘要作者：Joanna Depciuch、Paweł Jakubczyk、Wiesław Paja、Jaromir Sarzyński、Krzysztof Pancerz、Merve Açıkel Elmas、Elif Keskinöz、Özlem BingölÖzakpınar、Serap Arbak、Gökçe Özgün、Sevde Altuntaş、Zozan Guleken
文章归属：Joanna Depciuch
摘要：在此，我们检查了通过生化检测、傅里叶变换红外光谱（FTIR）和机器学习方法研究罗布麻（APO）对长期食用血清成分后味精（MSG）引起的大鼠脑组织氧化损伤的调节作用。 Sprague-Dawley雄性大鼠随机分组ed into the Control, Control + APO, MSG, and MSG + APO groups (n = 8 per group). All administrations were made by oral gavage saline, MSG, or APO and they were repeated for 28 days of the experiments.收集脑组织和血清样品，并分析Malondiardehyde（MDA），谷胱甘肽（GSH），髓过氧化物酶（MPO），超氧化物歧化酶（SOD）活性和光谱分析的测量水平。 After 29 days, the results were evaluated using machine learning (ML). The levels of MDA and MPO showed changes in the MSG and MSG + APO groups, respectively. Changes in the proteins and lipids were observed in the FTIR spectra of the MSG groups. Additionally, APO in these animals improved the FTIR spectra to be similar to those in the Control group. The accuracy of the FTIR results calculated by ML was 100%.这项研究的结果表明，apocynin治疗通过抑制氧化氧和上调抗氧化，可保护大量味精诱导的氧化损伤蚂蚁的容量，表明其在减轻味精的毒性作用方面的潜力。